Potential impact of nutritional intervention on end-stage renal disease hospitalization, death, and treatment costs. Lacson E et al. Journal of Renal Nutrition 2007, 17:363-371
Summary: In this hypothetical scenario, increasing the albumin by 0.2 g/dL had the potential to save 1400 lives, avert 6000 hospitalizations, and save $36 million Medicare dollars. Results showed decreased mortality, reduced treatment costs, and decreased hospitalization.
Severity of hypoalbuminemia predicts response to intradialytic parenteral nutrition in hemodialysis patients. Dezfuli A et al. Journal of Renal Nutrition 2009, 19:291-297
Summary: Patients with a serum albumin < 3 g/dL at baseline had a 2.5 times higher chance of increasing the albumin and a 3.8 times higher chance of increasing the albumin by at least 0.5 g/dL. Patients with lower albumin levels and diabetics respond the most dramatically.
The Use Of Intradialytic Parenteral nutrition In Acutely Ill Haemodialysed Patients. Korzets A et al. Journal of Renal Care, 34: 14–18. doi:10.1111/j.1755-6686.2008.00005.x
Summary: All studied parameters of nutrition and inflammation improved significantly while patients were treated with IDPN. Results included increase in protein catabolic rate (g protein/kg/day) 0.7 ± 0.2 to 1.2 ± 0.2, increase in albumin (g/l) 28 ± 5 to 38 ± 2 and decrease c-RP (mg/l) 77 ± 86 to 9 ±10.
Intradialytic parenteral nutrition (IDPN) leads to sustained increase of serum prealbumin (PA) levels in malnourished hemodialysis (HD). Marsen T.A. et al. Clinical Nutrition Supplements, Volume 7, Issue 1, Page 15.
Summary: Prealbumin is a nutritional parameter, positively correlated with reduced morbidity and survival in malnourished HD patients. The study addressed changes of PA during 16 weeks of IDPN in 107 malnourished HD patients and showed a significant increase of prealbumin (SG: +26.31 mg/l vs CG: 1.84 mg/l). Diabetic patients revealed higher increase of prealbumin (SG: +32.62 mg/l vs CG: 1.67 mg/l). Prealbumin elevation was maintained during 6 week follow-up period.
Nutrition support for the chronically wasted or acutely catabolic chronic kidney disease patient. Ikizler TA. Seminar of Nephrology. 2009, 29:75-84 [Meta-analysis]
Summary: Available evidence suggests that nutritional supplementation, administered orally or parenteral, is effective in the treatment of maintenance dialysis patients with protein-energy wasting in whom oral dietary intake from regular meals cannot maintain adequate nutritional stores. Increase serum albumin by 0.2 g/dL or greater considerable improvements in mortality, hospitalization, and treatment costs. IDPN promoted a 96% increase in whole-body protein synthesis, 50% decrease in whole-body proteolysis, and positive nitrogen.