Benefits of IDPN/IPN Therapies

IDPN and IPN therapies are a go-to for effectively increasing patient albumin and prealbumin levels. But did you know they also offer a number of other well-documented and proven benefits? Studies show they can prevent weight loss, decrease mortality and malnutrition and increase appetite in patients. The below studies outline the wide array of benefits provided by IDPN and/or IPN therapy.

Evidence-Based Benefits


Increase Albumin and Prealbumin


Severity Of Hypoalbuminemia Predicts Response To Intradialytic Parenteral Nutrition In Hemodialysis Patients

Increase Albumin, Prealbumin AND nPCR

Intradialytic Parenteral Nutrition: Effect on Albumin and Normalized Protein Catabolic Rate

Prevent PEW/Catabolic Effect Of Dialysis

Nutrition Support For The Chronically Wasted Or Acutely Catabolic Chronic Kidney Disease Patient

Prevent Weight Loss

Efficacy of Intradialytic Parenteral Nutrition in Malnourished Hemodialysis Patients, American Journal of Health-System Pharmacy

Exercise augments the acute anabolic effects of intradialytic parenteral nutrition in chronic hemodialysis patients

Prolonged Use of IDPN in Elderly Malnourished Chronic Hemodialysis Patients

New insight of amino acid-based dialysis solutions (IPN)

Decrease Malnutrition

Increase Appetite

Intradialytic hyperalimentation as adjuvant support in pregnant hemodialysis patients: case report and review of the literature.

Decrease Mortality

Intradialytic Parenteral Nutrition Does Not Improve Survival in Malnourished Hemodialysis Patients:  A 2-year Multicenter, Prospective, Randomized Study.

Reduced treatment costs; Decrease Mortality; Decrease Infection and Hospitalization Rates

Potential impact of nutritional intervention on end-stage renal disease hospitalization, death, and treatment costs.

Improve Inflammation Marker, Decrease c-RP Levels

The Use of Intradialytic Parenteral Nutrition in Acutely Ill Hemodialysis Patients

Effect of intradialytic parenteral nutrition in patients with malnutrition-inflammation complex syndrome on body weight, inflammation, serum lipids and adipocytokines: results from a pilot study.

Faster recovery from major surgery, such as limb amputations; or from other medical, infectious conditions, including chemotherapy

The Use of Intradialytic Parenteral Nutrition in Acutely Ill Hemodialysis Patients

The following supporting anecdotal and empirical evidence may be used to supplement some of the evidence-based medical literature referenced above.

  • In the short term, some transplant patients on IDPN and IPN therapy were able to maintain stability. Surgeons are hesitant to operate on patients with low albumin levels. Patients may also experience a swifter recovery after their transplant procedure.

  • Some patients also showed improved fluid balance.

  • Higher IDPN osmolarity (1400-2000 mOsm/L) encourages 3rd space fluids to enter the vasculature, dialysis machines can then remove that fluids by challenging patients weight.

  • The therapies may also promote wound healing due to reduced Inflammation and improved availability of plasma proteins, such as Albumin, Globulins and Fibrinogen.

 Patients also benefited from: 

  • Improved strength, body composition & overall well-being, leading to an overall, improved better quality of life
  • Increased hemoglobin, reduced EPO resistance and EPO usage. This was evidenced by the reduction of inflammation marker Ferritin, and the patient’s ability to utilize Iron more efficiently.

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