Benefits of IDPN/IPN Therapies
IDPN and IPN therapies are a go-to for effectively increasing patient albumin and prealbumin levels. But did you know they also offer a number of other well-documented and proven benefits? Studies show they can prevent weight loss, decrease mortality and malnutrition and increase appetite in patients. The below studies outline the wide array of benefits provided by IDPN and/or IPN therapy.
Evidence-Based Benefits
THERAPY BENEFITS
Increase Albumin and Prealbumin
SUPPORTING DOCUMENTATION
Severity Of Hypoalbuminemia Predicts Response To Intradialytic Parenteral Nutrition In Hemodialysis Patients http://www.jrnjournal.org/article/S1051-2276(09)00045-4/abstract
Increase Albumin, Prealbumin AND nPCR
Intradialytic Parenteral Nutrition: Effect on Albumin and Normalized Protein Catabolic Rate
Prevent PEW/Catabolic Effect Of Dialysis
Nutrition Support For The Chronically Wasted Or Acutely Catabolic Chronic Kidney Disease Patient http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3788638/
Prevent Weight Loss
Efficacy of Intradialytic Parenteral Nutrition in Malnourished Hemodialysis Patients, American Journal of Health-System Pharmacy http://www.ncbi.nlm.nih.gov/pubmed/12298111
Exercise augments the acute anabolic effects of intradialytic parenteral nutrition in chronic hemodialysis patients http://ajpendo.physiology.org/content/ajpendo/286/4/E589.full.pdf
Prolonged Use of IDPN in Elderly Malnourished Chronic Hemodialysis Patients http://www.ncbi.nlm.nih.gov/pubmed/9719170
New insight of amino acid-based dialysis solutions (IPN) http://www.ncbi.nlm.nih.gov/pubmed/17080099
Decrease Malnutrition
Increase Appetite
Intradialytic hyperalimentation as adjuvant support in pregnant hemodialysis patients: case report and review of the literature.
http://link.springer.com/article/10.1007%2Fs11255-009-9671-5
Decrease Mortality
Intradialytic Parenteral Nutrition Does Not Improve Survival in Malnourished Hemodialysis Patients: A 2-year Multicenter, Prospective, Randomized Study.
Reduced treatment costs; Decrease Mortality; Decrease Infection and Hospitalization Rates
Potential impact of nutritional intervention on end-stage renal disease hospitalization, death, and treatment costs. http://www.jrnjournal.org/article/S1051-2276(07)00177-X/abstract
Improve Inflammation Marker, Decrease c-RP Levels
The Use of Intradialytic Parenteral Nutrition in Acutely Ill Hemodialysis Patients
http://www.ncbi.nlm.nih.gov/pubmed/18336518
Effect of intradialytic parenteral nutrition in patients with malnutrition-inflammation complex syndrome on body weight, inflammation, serum lipids and adipocytokines: results from a pilot study.
http://www.nature.com/ejcn/journal/v62/n6/full/1602777a.html
Faster recovery from major surgery, such as limb amputations; or from other medical, infectious conditions, including chemotherapy
The Use of Intradialytic Parenteral Nutrition in Acutely Ill Hemodialysis Patients
The following supporting anecdotal and empirical evidence may be used to supplement some of the evidence-based medical literature referenced above.
In the short term, some transplant patients on IDPN and IPN therapy were able to maintain stability. Surgeons are hesitant to operate on patients with low albumin levels. Patients may also experience a swifter recovery after their transplant procedure.
Some patients also showed improved fluid balance.
Higher IDPN osmolarity (1400-2000 mOsm/L) encourages 3rd space fluids to enter the vasculature, dialysis machines can then remove that fluids by challenging patients weight.
The therapies may also promote wound healing due to reduced Inflammation and improved availability of plasma proteins, such as Albumin, Globulins and Fibrinogen.
Patients also benefited from:
- Improved strength, body composition & overall well-being, leading to an overall, improved better quality of life
- Increased hemoglobin, reduced EPO resistance and EPO usage. This was evidenced by the reduction of inflammation marker Ferritin, and the patient’s ability to utilize Iron more efficiently.